Cosmeceuticals | Phytosphingosines | Custom Synthesis | long-chain aliphatic 2-amino-1,3,4-triols/title> <meta http-equiv="Content-Type" content="text/html; charset=iso-8859-1"> <LINK href="style.css" rel=stylesheet> <link rel="shortcut icon" href="glycoteam.ico" > <script language="JavaScript" type="text/JavaScript">  </script> <meta name="description" content="cosmeceutical phytophingosines functional cosemtics antifungal antitumor custom synthesis glycoteam ."> <meta name="keywords" content="phytosphingosine, supply, supplier, custom synthesis, derivatives, cosmeceutical, antitumor, antifungal, long chain , aliphatic, , 2-amino-1,3,4-triols, carbohydrate, glycoteam"></head> <body bgcolor="#1D3E13" link="#333366" vlink="#333366" alink="#CC3333" topmargin="0"> <table width="66%" border="0" align="center" cellpadding="10" cellspacing="0" bgcolor="#FFFFFF"> <tr> <td> <table width="100%" border="0" cellspacing="12" cellpadding="0"> <tr> <td height="158" valign="top" class="headerblue"> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td><div align="right"> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td><A href="produkt_e4.html#M"><IMG name="glycoteam_sm" src="logo_b_small.gif" alt="Glycoteam GmbH" width="124" height="55" border="0" align="left" id="glycoteam_sm"></A><IMG src="spacer.gif" width="60" height="1" border="0"> <A href="order_e.html">Enquiry Form</A></td> <td><div align="right" class="smallg"><A href="MH_final.pdf"></a></div> <a href="phytosphingosine_e.htm"><img src="eng.gif" alt="ENGLISH" width="27" height="32" border="0" align="absmiddle"></a></td> </tr> </table> </div></td> </tr> </table> <a href="produkt_e4.html#M"></a> <p align="justify"><span class="headerred">Phytosphingosine</a></span> – finden zunehmend Eingang als aktive Inhaltsstoffe in funktionaler Kosmetik und in Dermatika sog. „Cosmeceuticals“ </p> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td bgcolor="#003399" height="2"><img src="spacer.gif" width="10" height="2" border="0"></td> </tr> </table> <img src="spacer.gif" width="10" height="5"><br> COSMECEUTICALS<br> <img src="spacer.gif" width="10" height="5"><br> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td bgcolor="#003399" height="2"><img src="spacer.gif" width="10" height="2" border="0"></td> </tr> </table></td> </tr> <tr> <td width="52%" valign="top"> <p align="justify" class="black"><span class="blacks">Cosmeceuticals</span> - <span class="blacks">Phytosphingosine</span> representieren <span class="red">eine Klasse von langkettigen 2-Amino-1,3,4-triolen</span>, die das charakteristische Rückgrat verschiedener Sphingolipide bilden.<br> </p> <p align="justify" class="black"> </p> <p align="center" class="black"><img src="phytosphingosine.gif" alt="Phytosphingosine" width="291" height="246"></p> <p align="center" class="black"><strong>"D-Ribo-Ceramide 3 Type"</strong></p> <p align="justify" class="black">Sie sind wichtige Bestandteile der Plasmamembran und spielen eine Schlüsselrolle in Zellrezeptormodulation, intrazellulärer Signaltransduktion und Immunantwort<sup>[1]</sup>. Darüberhinaus entfalten Sphingolipide interessante biologische Aktivitäten, wie <span class="blacks">antitumorigene</span><sup>[2a]</sup>, <span class="blacks">antivirale</span> <sup>[2b]</sup>, <span class="blacks">antifungale</span><sup>[2c]</sup>, oder <span class="blacks">cytotoxische</span><sup>[2d]</sup> Wirkung. Demzufolge sind Sphingolipide interessante Ziele für biochemische Untersuchungen und biomedizinische Anwendungen. Als integraler Bestandteil des menschlichen <em>Stratum Corneums</em>, der äußersten Schicht der Epidermis, finden Phytosphingoceramide zunehmend Eingang als aktive Inhaltsstoffe in funktionaler Kosmetik und in Dermatika<sup>[3] </sup>(sog. „Cosmeceuticals“).<br> <br> <img src="green.jpg" width="763" height="44"></p> <p align="justify" class="red">Unsere neuartige Synthese ermöglicht eine variationsreiche Synthese einer vielzahl von Derivaten. Preise erhalten Sie auf Anfrage. <br> Wir richten uns nach Ihren speziellen Wünschen (Auftragssynthese) und bieten auch fluoreszierend markierte Strukturen auf Anfrage. </p></td> </tr> </table> <div align="center"> <table width="100%" border="0" cellspacing="12" cellpadding="0"> <tr> <td colspan="2" valign="top"><br> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td bgcolor="#003399" height="2"><img src="spacer.gif" width="10" height="2" border="0"></td> </tr> </table> <span class="black"><img src="spacer.gif" width="10" height="5"><br> <span class="blacks">References</span><br> <img src="spacer.gif" width="10" height="5"> <table width="100%" border="0" cellspacing="0" cellpadding="0"> <tr> <td bgcolor="#003399" height="2"><img src="spacer.gif" width="10" height="2" border="0"></td> </tr> </table></td> </tr> <tr> <td width="50%" height="168" valign="top" class="black"> <p align="justify">[1] (a) Reviews: T. Kolter and K. Sandhoff, Angew. Chem., Int. Ed., 1999, 38, 1532; (b) S. Brodesser, P. Sawatzki and T. Kolter, Eur. J. Org. Chem., 2003, 2021; (c) T. Kolter, Conformational Restriction of Sphingolipids, in Highlights Bioorganic Chemistry: Methods and Applications, ed. C. Schmuck and H. Wennemers, Wiley-VCH, Weinheim, 2004, ch. 1.4, p. 48; (d) J. Liao, J. Tao, G. Lin and D. Liu, Tetrahedron, 2005, 61, 4715. <br> <br> [2] (a) T. Naroti,M.Morita, K. Akimoto and Y. Koezuka, Tetrahedron, 1994, 50, 2771; (b) H.Kamitakahara, T. Suzuki,N.Nishigori,Y. Suzuki, O. Kamie and C.-H. Wong, Angew. Chem., Int. Ed., 1998, 37, 1524; <br> </p> </td> <td valign="top" width="50%" class="black"><p align="justify">[2] (c) S. Kobayashi, T. Furuta, T. Hayashi, M. Nishijima and K. Hanada, J. Am. Chem. Soc., 1998, 120, 908; (d) H. Li, S. Matsunaga and N. Fusetani, Tetrahedron, 1995, 51, 2273. <br> <br> [3] (a) S. Wartewig, R.H.H. Neubert, Skin Pharmacol Physiol 2007;20:220–229; (b) Patrick Garidel, Exog Dermatol 2004;3:131–143; (c) United States Patent 6001375 : Topical application of ceramides; (d) WO 2004064823 A1: Ceramide compounds and modulators for the treatment of inflammation. (e) Combination of antiadhesives (ceramides, sphingosines, and derivatives) and microbicides. DE 19841794 A1; (f) Cosmetic method for the care of greasy skin and kit therefor. EP 1759688 A1. <br> </p> </td> </tr> </table> </div> </td> </tr> <tr> <td><table width="100%" border="0" cellpadding="0" cellspacing="0"> <tr> <td bgcolor="#CCCCCC" height="2"><img src="spacer.gif" width="10" height="1" border="0"></td> </tr> <tr> <td height="30" class="small"><div align="center"> <a href="about_e.html">ABOUT US</a> <font color="#CC0033">|</font> <A href="produkt_e1.html">PRODUCTS</a> <font color="#CC0033">|</font> <A href="analytik_e.html">ANALYTIC</a> <font color="#CC0033">|</font> <A href="referenz_e.html">REFERENCES</a> <font color="#CC0033">|</font> <A href="order_e.html">ENQUIRY FORM</a> <font color="#CC0033">|</font> <A href="jobs_e.html">CAREERS</a></div></td> </tr> <tr> <td bgcolor="#CCCCCC" height="2"><img src="spacer.gif" width="10" height="1" border="0"></td> </tr> <tr> <td height="2">Copyright © 2007 Glycoteam GmbH </td> </tr> <tr> <td height="2"></td> </tr> </table></td> </tr> </table> </body> </html>